学术论文

Zhongyuan Yang, Yiming Tang, Jitao Wen, Cong Guo, Yun Zhou, Zihan Wang, Tong Pan, Yuan Tan, Sarah Perrett, Si Wu, Guanghong Wei

Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α-Synuclein Phase Separation

发表于 JACS Au, 2026.

Yanning Zhen, Yuan Tan, Yiming Tang, Tomas Sneideris, Hannes Ausserwöger, Jitao Wen, Tuomas P. J. Knowles, Sarah Perrett, Guanghong Wei, Si Wu

NPM1 Undergoes Salt‐Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk

发表于 Small, 2026.

Hui Yuan, Zhongyuan Yang, Chengqian Yuan, Sudha Shankar, Aviad Levin, Tiancheng Lv, Zihan Wang, Wei Sun, Jadon Sitton, Pierre-Andre Cazade, Yoav Dan, Yiming Tang, Lihi Adler-Abramovich, Yi Cao, Sigal Rencus-Lazar, Damien Thompson, Dmitry Kurouski, Tuomas P. J. Knowles, Linda J. W. Shimon, Guanghong Wei, Bin Xue, Rusen Yang, Ehud Gazit

Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers

发表于 Nature Communications, 2026.

Xun Sun, Yiming Tang, Xue Wang, Guadalupe Pereira Curia, Rebecca Sternke-Hoffmann, Cecilia Mörman, Juan Atilio Gerez, Roland Riek, Guanghong Wei, Jinghui Luo

Alzheimer’s Aβ catalyzes Tau phase separation and aggregation via early nanocluster solubilization

发表于 Nature Communications, 2026. 代表作

Yan Zhang, Tong Pan, Sarah Guerin, Jiahao Zhang, Yiming Tang, Zengfeng Qiu, Qi Li, Jiaojiao Zhang, Feng Wei, Jiqian Wang, Rusen Yang, Deqing Mei, Damien Thompson, Guanghong Wei, Hai Xu, Kai Tao

Underlying Polymorphism: Superhelical Crystallization Induces Architectural and Functional Diversity

发表于 Small, 2026.

Vivek Vishwanath Adole, Zichao Wang, Yiming Tang, Gayatri Mishra, Ipsita Sahu, Guanghong Wei, Priyadarshi Chakraborty

Histidine Containing Minimalistic‐Peptide‐Based Nanostructured Hydrogel for Multiple Enzyme‐Mimicking Catalytic Activities

发表于 Small, 2025.

Yiming Tang, Zhongyuan Yang, Junli Yang, Jiyuan Zeng, Yuan Tan, Yifei Yao, Wei Ji, Ehud Gazit, Guanghong Wei

Stoichiometry-Controlled Structural Transformation of Diphenylalanine Nanoassemblies through Coassembly with Charged Dipeptides

发表于 JACS Au, 2025. 代表作

Yiming Tang, Jitao Wen, Zhongyuan Yang, Yifei Yao, Shaoshuai He, Jiyuan Zeng, Xuewei Dong, Qin Qiao, Yun Zhou, Sarah Perrett, Si Wu, Guanghong Wei

Dissecting the Molecular Determinants of α‐synuclein Phase Separation and Condensate Aging: The Pivotal Role of β‐Sheet‐Rich Motifs

发表于 Advanced Science, 2025. 代表作

Jitao Wen, Yiming Tang, Tomas Sneideris, Hannes Ausserwöger, Liu Hong, Tuomas P. J. Knowles, Sarah Perrett, Guanghong Wei, Si Wu

Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior

发表于 JACS Au, 2025.

Haoxin Sun, Jingbo Wei, Yiming Tang, Tianjing Guo, Guanghong Wei, Jiangtao Lei

Comparative Study of a Variant Neural Relational Inference Deep Learning Model and Dynamical Network Analysis for p53-DNA Allosteric Interactions

发表于 Journal of Molecular Biology, 2025.

Yoav Dan, Zohar A. Arnon, Yiming Tang, Mathar Kravikass, Yun Zhou, Rajkumar Misra, Om Shanker Tiwari, Linda J. W. Shimon, Roy Beck, Ehud Gazit, Guanghong Wei, Lihi Adler-Abramovich

Effect of solvent-induced packing transitions on N-capped diphenylalanine peptide crystal growth

发表于 Nature Communications, 2025.

Tong Pan, Yuan Tan, Xuewei Dong, Yiming Tang, Zhongyuan Yang, Yujie Chen, Guanghong Wei

Elucidating How Terminal Capping of Tau Hexapeptide PHF6 Modulates the Interactions between PHF6 Fibrils and Membranes

发表于 The Journal of Physical Chemistry B, 2025.

Yuan Tan, Yujie Chen, Tong Pan, Yiming Tang, Xianshi Liu, Yawei Yu, Guanghong Wei

Computational Exploration of the Inhibitory Mechanism of mRNA against the Phase Separation of hnRNPA2 Low Complexity Domains

发表于 Journal of Chemical Information and Modeling, 2025.

Xinyuan Fan, Yiming Tang, Jiahao Zhang, Kang Ma, Zhengyu Xu, Yuying Liu, Bin Xue, Yi Cao, Deqing Mei, Wei Wang, Guanghong Wei, Kai Tao

Gaseous Synergistic Self‐Assembly and Arraying to Develop Bio‐Organic Photocapacitors for Neural Photostimulation

发表于 Advanced Science, 2025.

Yujie Chen, Xun Sun, Yiming Tang, Yuan Tan, Cong Guo, Tong Pan, Xuefeng Zhang, Jinghui Luo, Guanghong Wei

Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule‐Binding Domain and Enhances Liquid‐Liquid Phase Separation of Tau

发表于 Small, 2025.

Jiyuan Zeng, Zhongyuan Yang, Yiming Tang, Guanghong Wei

Emerging Frontiers in Conformational Exploration of Disordered Proteins: Integrating Autoencoder and Molecular Simulations

发表于 ACS Chemical Neuroscience, 2024.

Yawei Yu, Qian Liu, Jiyuan Zeng, Yuan Tan, Yiming Tang, Guanghong Wei

Multiscale simulations reveal the driving forces of p53C phase separation accelerated by oncogenic mutations

发表于 Chemical Science, 2024.

Yiming Tang, Zhongyuan Yang, Yifei Yao, Yun Zhou, Yuan Tan, Zichao Wang, Tong Pan, Rui Xiong, Junli Sun, Guanghong Wei

Recent advances in protein conformation sampling by combining machine learning with molecular simulation

发表于 Chinese Physics B, 2024.

Zenghui Lao, Yiming Tang, Xuewei Dong, Yuan Tan, Xuhua Li, Xianshi Liu, Le Li, Cong Guo, Guanghong Wei

Elucidating the reversible and irreversible self-assembly mechanisms of low-complexity aromatic-rich kinked peptides and steric zipper peptides

发表于 Nanoscale, 2024.

Ipsita Sahu, Yiming Tang, Zichao Wang, Souvik Naskar, Thangavel Vijayakanth, Vivek Vishwanath Adole, Guanghong Wei, Priyadarshi Chakraborty

Bioinspired functional self-healing hydrogels from a minimalistic dipeptide building block

发表于 Journal of Materials Chemistry A, 2024.

Jiyuan Zeng, Yiming Tang, Xuewei Dong, Fangying Li, Guanghong Wei

Influence of ALS ‐linked M337V mutation on the conformational ensembles of TDP‐43 321–340 peptide monomer and dimer

发表于 Proteins: Structure, Function, and Bioinformatics, 2024.

唐一鸣, 姚逸飞, 杨中元, 周运, 王子超, 韦广红

神经退行性疾病相关蛋白病理性聚集和液液相分离研究进展

Pathological aggregation and liquid-liquid phase separation of proteins associated with neurodegenerative diseases

发表于 合成生物学, 2023.

Fangying Li, Yujie Chen, Yiming Tang, Xianshi Liu, Guanghong Wei

Dissecting the Effect of ALS Mutation G335D on the Early Aggregation of the TDP-43 Amyloidogenic Core Peptide: Helix-to-β-Sheet Transition and Conformational Shift

发表于 Journal of Chemical Information and Modeling, 2023.

Yuan Tan, Yujie Chen, Xianshi Liu, Yiming Tang, Zenghui Lao, Guanghong Wei

Dissecting how ALS-associated D290V mutation enhances pathogenic aggregation of hnRNPA2286–291 peptides: Dynamics and conformational ensembles

发表于 International Journal of Biological Macromolecules, 2023.

Zhongyuan Yang, Yifei Yao, Yun Zhou, Xuhua Li, Yiming Tang, Guanghong Wei

EGCG attenuates α-synuclein protofibril-membrane interactions and disrupts the protofibril

发表于 International Journal of Biological Macromolecules, 2023.

Yun Zhou, Yifei Yao, Zhongyuan Yang, Yiming Tang, Guanghong Wei

Naphthoquinone–dopamine hybrids disrupt α-synuclein fibrils by their intramolecular synergistic interactions with fibrils and display a better effect on fibril disruption

发表于 Physical Chemistry Chemical Physics, 2023.

Fangying Li, Yujie Chen, Xianshi Liu, Yiming Tang, Xuewei Dong, Guanghong Wei

Atomistic Insights into A315E Mutation-Enhanced Pathogenicity of TDP-43 Core Fibrils

发表于 ACS Chemical Neuroscience, 2022.

Yifei Yao, Yiming Tang, Yun Zhou, Zhongyuan Yang, Guanghong Wei

Baicalein exhibits differential effects and mechanisms towards disruption of α-synuclein fibrils with different polymorphs

发表于 International Journal of Biological Macromolecules, 2022.

Rajkumar Misra, Yiming Tang, Yujie Chen, Priyadarshi Chakraborty, Francesca Netti, Thangavel Vijayakanth, Linda J. W. Shimon, Guanghong Wei, Lihi Adler‐Abramovich

Exploiting Minimalistic Backbone Engineered γ ‐Phenylalanine for the Formation of Supramolecular Co‐Polymer

发表于 Macromolecular Rapid Communications, 2022.

Zenghui Lao, Xuewei Dong, Xianshi Liu, Fangying Li, Yujie Chen, Yiming Tang, Guanghong Wei

Insights into the Atomistic Mechanisms of Phosphorylation in Disrupting Liquid–Liquid Phase Separation and Aggregation of the FUS Low-Complexity Domain

发表于 Journal of Chemical Information and Modeling, 2022.

Le Li, Xuewei Dong, Yiming Tang, Zenghui Lao, Xuhua Li, Jiangtao Lei, Guanghong Wei

Deciphering the mechanisms of HPV E6 mutations in the destabilization of E6/E6AP/p53 complex

发表于 Biophysical Journal, 2022.

Yawei Yu, Xuewei Dong, Yiming Tang, Le Li, Guanghong Wei

Mechanistic insight into the destabilization of p53TD tetramer by cancer-related R337H mutation: a molecular dynamics study

发表于 Physical Chemistry Chemical Physics, 2022.

Wei Ji, Yiming Tang, Pandeeswar Makam, Yifei Yao, Ranran Jiao, Kaiyong Cai, Guanghong Wei, Ehud Gazit

Expanding the Structural Diversity and Functional Scope of Diphenylalanine-Based Peptide Architectures by Hierarchical Coassembly

发表于 Journal of the American Chemical Society, 2021.

Yiming Tang, Santu Bera, Yifei Yao, Jiyuan Zeng, Zenghui Lao, Xuewei Dong, Ehud Gazit, Guanghong Wei

Prediction and characterization of liquid-liquid phase separation of minimalistic peptides

发表于 Cell Reports Physical Science, 2021. 代表作

Yiming Tang, Yifei Yao, Guanghong Wei

Unraveling the Allosteric Mechanism of Four Cancer-related Mutations in the Disruption of p53-DNA Interaction

发表于 The Journal of Physical Chemistry B, 2021.

Priyadarshi Chakraborty, Hadas Oved, Darya Bychenko, Yifei Yao, Yiming Tang, Shai Zilberzwige‐Tal, Guanghong Wei, Tal Dvir, Ehud Gazit

Nanoengineered Peptide‐Based Antimicrobial Conductive Supramolecular Biomaterial for Cardiac Tissue Engineering

发表于 Advanced Materials, 2021.

Santu Bera, Xuewei Dong, Bankala Krishnarjuna, Shannon A. Raab, David A. Hales, Wei Ji, Yiming Tang, Linda J.W. Shimon, Ayyalusamy Ramamoorthy, David E. Clemmer, Guanghong Wei, Ehud Gazit

Solid-state packing dictates the unexpected solubility of aromatic peptides

发表于 Cell Reports Physical Science, 2021.

Xuewei Dong, Santu Bera, Qin Qiao, Yiming Tang, Zenghui Lao, Yin Luo, Ehud Gazit, Guanghong Wei

Liquid–Liquid Phase Separation of Tau Protein Is Encoded at the Monomeric Level

发表于 The Journal of Physical Chemistry Letters, 2021.

Xuewei Dong, Yiming Tang, Chendi Zhan, Guanghong Wei

Green tea extract EGCG plays a dual role in Aβ42 protofibril disruption and membrane protection: A molecular dynamic study

发表于 Chemistry and Physics of Lipids, 2021.

Chendi Zhan, Zenghui Lao, Yiming Tang, Qin Qiao, Guanghong Wei

Natural stereoisomeric flavonoids exhibit different disruptive effects and the mechanism of action on Aβ 42 protofibril

发表于 Chemical Communications, 2021.

Yifei Yao, Yiming Tang, Guanghong Wei

Epigallocatechin Gallate Destabilizes α-Synuclein Fibril by Disrupting the E46–K80 Salt-Bridge and Inter-protofibril Interface

发表于 ACS Chemical Neuroscience, 2020.

Priyadarshi Chakraborty, Yiming Tang, Tom Guterman, Zohar A. Arnon, Yifei Yao, Guanghong Wei, Ehud Gazit

Co‐Assembly between Fmoc Diphenylalanine and Diphenylalanine within a 3D Fibrous Viscous Network Confers Atypical Curvature and Branching

发表于 Angewandte Chemie International Edition, 2020.

Yiming Tang, Yifei Yao, Guanghong Wei

Structural and dynamical mechanisms of a naturally occurring variant of the human prion protein in preventing prion conversion

发表于 Chinese Physics B, 2020.

Kai Tao, Yiming Tang, Sigal Rencus‐Lazar, Yifei Yao, Bin Xue, Sharon Gilead, Guanghong Wei, Ehud Gazit

Bioinspired Supramolecular Packing Enables High Thermo‐Sustainability

发表于 Angewandte Chemie International Edition, 2020.

Chendi Zhan, Yujie Chen, Yiming Tang, Guanghong Wei

Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ42 Protofibril

发表于 ACS Chemical Neuroscience, 2020.

Cuiqin Bai, Zenghui Lao, Yujie Chen, Yiming Tang, Guanghong Wei

Pristine and Hydroxylated Fullerenes Prevent the Aggregation of Human Islet Amyloid Polypeptide and Display Different Inhibitory Mechanisms

发表于 Frontiers in Chemistry, 2020.

Priyadarshi Chakraborty, Yiming Tang, Tomoya Yamamoto, Yifei Yao, Tom Guterman, Shai Zilberzwige‐Tal, Nofar Adadi, Wei Ji, Tal Dvir, Ayyalusamy Ramamoorthy, Guanghong Wei, Ehud Gazit

Unusual Two‐Step Assembly of a Minimalistic Dipeptide‐Based Functional Hypergelator

发表于 Advanced Materials, 2020.

Yiming Tang, Yifei Yao, Guanghong Wei

Expanding the structural diversity of peptide assemblies by coassembling dipeptides with diphenylalanine

发表于 Nanoscale, 2020.

Le Li, Xuhua Li, Yiming Tang, Zenghui Lao, Jiangtao Lei, Guanghong Wei

Common cancer mutations R175H and R273H drive the p53 DNA-binding domain towards aggregation-prone conformations

发表于 Physical Chemistry Chemical Physics, 2020.

Yu Zou, Zhenyu Qian, Yehong Gong, Yiming Tang, Guanghong Wei, Qingwen Zhang

Critical nucleus of Greek-key-like core of α-synuclein protofibril and its disruption by dopamine and norepinephrine

发表于 Physical Chemistry Chemical Physics, 2020.

Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J. W. Shimon, Michael R. Sawaya, Sofiya Kolusheva, David S. Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei, Ehud Gazit

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

发表于 Nature Communications, 2019.

Hongqing Wang, Qian Xu, Zhihua Liu, Yiming Tang, Guanghong Wei, Y. Ron Shen, Wei-Tao Liu

Gate-Controlled Sum-Frequency Vibrational Spectroscopy for Probing Charged Oxide/Water Interfaces

发表于 The Journal of Physical Chemistry Letters, 2019.

Zenghui Lao, Yujie Chen, Yiming Tang, Guanghong Wei

Molecular Dynamics Simulations Reveal the Inhibitory Mechanism of Dopamine against Human Islet Amyloid Polypeptide (hIAPP) Aggregation and Its Destabilization Effect on hIAPP Protofibrils

发表于 ACS Chemical Neuroscience, 2019.

Vasantha Basavalingappa, Tom Guterman, Yiming Tang, Sivan Nir, Jiangtao Lei, Priyadarshi Chakraborty, Lee Schnaider, Meital Reches, Guanghong Wei, Ehud Gazit

Expanding the Functional Scope of the Fmoc‐Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification

发表于 Advanced Science, 2019.

Santu Bera, Sudipta Mondal, Yiming Tang, Guy Jacoby, Elad Arad, Tom Guterman, Raz Jelinek, Roy Beck, Guanghong Wei, Ehud Gazit

Deciphering the Rules for Amino Acid Co-Assembly Based on Interlayer Distances

发表于 ACS Nano, 2019.

Yuxiang Mo, Sayanti Brahmachari, Jiangtao Lei, Sharon Gilead, Yiming Tang, Ehud Gazit, Guanghong Wei

The Inhibitory Effect of Hydroxylated Carbon Nanotubes on the Aggregation of Human Islet Amyloid Polypeptide Revealed by a Combined Computational and Experimental Study

发表于 ACS Chemical Neuroscience, 2018.

Hongsheng Qian, Yu Zou, Yiming Tang, Yehong Gong, Zhenyu Qian, Guanghong Wei, Qingwen Zhang

Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel–Lindau tumor suppressor protein

发表于 Physical Chemistry Chemical Physics, 2018.

Yiming Tang, Guanghong Wei

Dissecting the Structural Mechanism of a Naturally Occuring Variant of the Prion Protein in Preventing Prion Disease

发表于 Biophysical Journal, 2018.