PUBLICATIONS

Last updated 2026-09-17

Publications

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1,759

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Based on 58 public publications · Google Scholar

2026

Zhongyuan Yang, Yiming Tang, Jitao Wen, Cong Guo, Yun Zhou, Zihan Wang, Tong Pan, Yuan Tan, Sarah Perrett, Si Wu, Guanghong Wei

Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α-Synuclein Phase Separation

In JACS Au, 2026.

doi:10.1021/jacsau.6c00631

Yanning Zhen, Yuan Tan, Yiming Tang, Tomas Sneideris, Hannes Ausserwöger, Jitao Wen, Tuomas P. J. Knowles, Sarah Perrett, Guanghong Wei, Si Wu

NPM1 Undergoes Salt‐Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk

In Small, 2026.

doi:10.1002/smll.202514678

Hui Yuan, Zhongyuan Yang, Chengqian Yuan, Sudha Shankar, Aviad Levin, Tiancheng Lv, Zihan Wang, Wei Sun, Jadon Sitton, Pierre-Andre Cazade, Yoav Dan, Yiming Tang, Lihi Adler-Abramovich, Yi Cao, Sigal Rencus-Lazar, Damien Thompson, Dmitry Kurouski, Tuomas P. J. Knowles, Linda J. W. Shimon, Guanghong Wei, Bin Xue, Rusen Yang, Ehud Gazit

Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers

In Nature Communications, 2026.

doi:10.1038/s41467-026-71043-5

Xun Sun, Yiming Tang, Xue Wang, Guadalupe Pereira Curia, Rebecca Sternke-Hoffmann, Cecilia Mörman, Juan Atilio Gerez, Roland Riek, Guanghong Wei, Jinghui Luo

Alzheimer’s Aβ catalyzes Tau phase separation and aggregation via early nanocluster solubilization

In Nature Communications, 2026. Selected

doi:10.1038/s41467-026-70083-1

Yan Zhang, Tong Pan, Sarah Guerin, Jiahao Zhang, Yiming Tang, Zengfeng Qiu, Qi Li, Jiaojiao Zhang, Feng Wei, Jiqian Wang, Rusen Yang, Deqing Mei, Damien Thompson, Guanghong Wei, Hai Xu, Kai Tao

Underlying Polymorphism: Superhelical Crystallization Induces Architectural and Functional Diversity

In Small, 2026.

doi:10.1002/smll.202510542

2025

Vivek Vishwanath Adole, Zichao Wang, Yiming Tang, Gayatri Mishra, Ipsita Sahu, Guanghong Wei, Priyadarshi Chakraborty

Histidine Containing Minimalistic‐Peptide‐Based Nanostructured Hydrogel for Multiple Enzyme‐Mimicking Catalytic Activities

In Small, 2025.

doi:10.1002/smll.202511661

Yiming Tang, Zhongyuan Yang, Junli Yang, Jiyuan Zeng, Yuan Tan, Yifei Yao, Wei Ji, Ehud Gazit, Guanghong Wei

Stoichiometry-Controlled Structural Transformation of Diphenylalanine Nanoassemblies through Coassembly with Charged Dipeptides

In JACS Au, 2025. Selected

doi:10.1021/jacsau.5c00996

Yiming Tang, Jitao Wen, Zhongyuan Yang, Yifei Yao, Shaoshuai He, Jiyuan Zeng, Xuewei Dong, Qin Qiao, Yun Zhou, Sarah Perrett, Si Wu, Guanghong Wei

Dissecting the Molecular Determinants of α‐synuclein Phase Separation and Condensate Aging: The Pivotal Role of β‐Sheet‐Rich Motifs

In Advanced Science, 2025. Selected

doi:10.1002/advs.202511545

Jitao Wen, Yiming Tang, Tomas Sneideris, Hannes Ausserwöger, Liu Hong, Tuomas P. J. Knowles, Sarah Perrett, Guanghong Wei, Si Wu

Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior

In JACS Au, 2025.

doi:10.1021/jacsau.5c00625

Haoxin Sun, Jingbo Wei, Yiming Tang, Tianjing Guo, Guanghong Wei, Jiangtao Lei

Comparative Study of a Variant Neural Relational Inference Deep Learning Model and Dynamical Network Analysis for p53-DNA Allosteric Interactions

In Journal of Molecular Biology, 2025.

doi:10.1016/j.jmb.2025.169374

Yoav Dan, Zohar A. Arnon, Yiming Tang, Mathar Kravikass, Yun Zhou, Rajkumar Misra, Om Shanker Tiwari, Linda J. W. Shimon, Roy Beck, Ehud Gazit, Guanghong Wei, Lihi Adler-Abramovich

Effect of solvent-induced packing transitions on N-capped diphenylalanine peptide crystal growth

In Nature Communications, 2025.

doi:10.1038/s41467-025-61331-x

Tong Pan, Yuan Tan, Xuewei Dong, Yiming Tang, Zhongyuan Yang, Yujie Chen, Guanghong Wei

Elucidating How Terminal Capping of Tau Hexapeptide PHF6 Modulates the Interactions between PHF6 Fibrils and Membranes

In The Journal of Physical Chemistry B, 2025.

doi:10.1021/acs.jpcb.5c01590

Yuan Tan, Yujie Chen, Tong Pan, Yiming Tang, Xianshi Liu, Yawei Yu, Guanghong Wei

Computational Exploration of the Inhibitory Mechanism of mRNA against the Phase Separation of hnRNPA2 Low Complexity Domains

In Journal of Chemical Information and Modeling, 2025.

doi:10.1021/acs.jcim.5c00321

Xinyuan Fan, Yiming Tang, Jiahao Zhang, Kang Ma, Zhengyu Xu, Yuying Liu, Bin Xue, Yi Cao, Deqing Mei, Wei Wang, Guanghong Wei, Kai Tao

Gaseous Synergistic Self‐Assembly and Arraying to Develop Bio‐Organic Photocapacitors for Neural Photostimulation

In Advanced Science, 2025.

doi:10.1002/advs.202410471

Yujie Chen, Xun Sun, Yiming Tang, Yuan Tan, Cong Guo, Tong Pan, Xuefeng Zhang, Jinghui Luo, Guanghong Wei

Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule‐Binding Domain and Enhances Liquid‐Liquid Phase Separation of Tau

In Small, 2025.

doi:10.1002/smll.202406429

2024

Jiyuan Zeng, Zhongyuan Yang, Yiming Tang, Guanghong Wei

Emerging Frontiers in Conformational Exploration of Disordered Proteins: Integrating Autoencoder and Molecular Simulations

In ACS Chemical Neuroscience, 2024.

doi:10.1021/acschemneuro.4c00670

Yawei Yu, Qian Liu, Jiyuan Zeng, Yuan Tan, Yiming Tang, Guanghong Wei

Multiscale simulations reveal the driving forces of p53C phase separation accelerated by oncogenic mutations

In Chemical Science, 2024.

doi:10.1039/d4sc03645j

Yiming Tang, Zhongyuan Yang, Yifei Yao, Yun Zhou, Yuan Tan, Zichao Wang, Tong Pan, Rui Xiong, Junli Sun, Guanghong Wei

Recent advances in protein conformation sampling by combining machine learning with molecular simulation

In Chinese Physics B, 2024.

doi:10.1088/1674-1056/ad1a92

Zenghui Lao, Yiming Tang, Xuewei Dong, Yuan Tan, Xuhua Li, Xianshi Liu, Le Li, Cong Guo, Guanghong Wei

Elucidating the reversible and irreversible self-assembly mechanisms of low-complexity aromatic-rich kinked peptides and steric zipper peptides

In Nanoscale, 2024.

doi:10.1039/d3nr05130g

Ipsita Sahu, Yiming Tang, Zichao Wang, Souvik Naskar, Thangavel Vijayakanth, Vivek Vishwanath Adole, Guanghong Wei, Priyadarshi Chakraborty

Bioinspired functional self-healing hydrogels from a minimalistic dipeptide building block

In Journal of Materials Chemistry A, 2024.

doi:10.1039/d3ta06663k

Jiyuan Zeng, Yiming Tang, Xuewei Dong, Fangying Li, Guanghong Wei

Influence of ALS ‐linked M337V mutation on the conformational ensembles of TDP‐43 321–340 peptide monomer and dimer

In Proteins: Structure, Function, and Bioinformatics, 2024.

doi:10.1002/prot.26482

2023

唐一鸣, 姚逸飞, 杨中元, 周运, 王子超, 韦广红

Pathological aggregation and liquid-liquid phase separation of proteins associated with neurodegenerative diseases

In 合成生物学, 2023.

doi:10.12211/2096-8280.2023-005

Fangying Li, Yujie Chen, Yiming Tang, Xianshi Liu, Guanghong Wei

Dissecting the Effect of ALS Mutation G335D on the Early Aggregation of the TDP-43 Amyloidogenic Core Peptide: Helix-to-β-Sheet Transition and Conformational Shift

In Journal of Chemical Information and Modeling, 2023.

doi:10.1021/acs.jcim.3c00513

Yuan Tan, Yujie Chen, Xianshi Liu, Yiming Tang, Zenghui Lao, Guanghong Wei

Dissecting how ALS-associated D290V mutation enhances pathogenic aggregation of hnRNPA2286–291 peptides: Dynamics and conformational ensembles

In International Journal of Biological Macromolecules, 2023.

doi:10.1016/j.ijbiomac.2023.124659

Zhongyuan Yang, Yifei Yao, Yun Zhou, Xuhua Li, Yiming Tang, Guanghong Wei

EGCG attenuates α-synuclein protofibril-membrane interactions and disrupts the protofibril

In International Journal of Biological Macromolecules, 2023.

doi:10.1016/j.ijbiomac.2023.123194

Yun Zhou, Yifei Yao, Zhongyuan Yang, Yiming Tang, Guanghong Wei

Naphthoquinone–dopamine hybrids disrupt α-synuclein fibrils by their intramolecular synergistic interactions with fibrils and display a better effect on fibril disruption

In Physical Chemistry Chemical Physics, 2023.

doi:10.1039/d3cp00340j

2022

Fangying Li, Yujie Chen, Xianshi Liu, Yiming Tang, Xuewei Dong, Guanghong Wei

Atomistic Insights into A315E Mutation-Enhanced Pathogenicity of TDP-43 Core Fibrils

In ACS Chemical Neuroscience, 2022.

doi:10.1021/acschemneuro.2c00416

Yifei Yao, Yiming Tang, Yun Zhou, Zhongyuan Yang, Guanghong Wei

Baicalein exhibits differential effects and mechanisms towards disruption of α-synuclein fibrils with different polymorphs

In International Journal of Biological Macromolecules, 2022.

doi:10.1016/j.ijbiomac.2022.08.088

Rajkumar Misra, Yiming Tang, Yujie Chen, Priyadarshi Chakraborty, Francesca Netti, Thangavel Vijayakanth, Linda J. W. Shimon, Guanghong Wei, Lihi Adler‐Abramovich

Exploiting Minimalistic Backbone Engineered γ ‐Phenylalanine for the Formation of Supramolecular Co‐Polymer

In Macromolecular Rapid Communications, 2022.

doi:10.1002/marc.202200223

Zenghui Lao, Xuewei Dong, Xianshi Liu, Fangying Li, Yujie Chen, Yiming Tang, Guanghong Wei

Insights into the Atomistic Mechanisms of Phosphorylation in Disrupting Liquid–Liquid Phase Separation and Aggregation of the FUS Low-Complexity Domain

In Journal of Chemical Information and Modeling, 2022.

doi:10.1021/acs.jcim.2c00414

Le Li, Xuewei Dong, Yiming Tang, Zenghui Lao, Xuhua Li, Jiangtao Lei, Guanghong Wei

Deciphering the mechanisms of HPV E6 mutations in the destabilization of E6/E6AP/p53 complex

In Biophysical Journal, 2022.

doi:10.1016/j.bpj.2022.03.030

Yawei Yu, Xuewei Dong, Yiming Tang, Le Li, Guanghong Wei

Mechanistic insight into the destabilization of p53TD tetramer by cancer-related R337H mutation: a molecular dynamics study

In Physical Chemistry Chemical Physics, 2022.

doi:10.1039/d1cp05670k

2021

Wei Ji, Yiming Tang, Pandeeswar Makam, Yifei Yao, Ranran Jiao, Kaiyong Cai, Guanghong Wei, Ehud Gazit

Expanding the Structural Diversity and Functional Scope of Diphenylalanine-Based Peptide Architectures by Hierarchical Coassembly

In Journal of the American Chemical Society, 2021.

doi:10.1021/jacs.1c07915

Yiming Tang, Santu Bera, Yifei Yao, Jiyuan Zeng, Zenghui Lao, Xuewei Dong, Ehud Gazit, Guanghong Wei

Prediction and characterization of liquid-liquid phase separation of minimalistic peptides

In Cell Reports Physical Science, 2021. Selected

doi:10.1016/j.xcrp.2021.100579

Yiming Tang, Yifei Yao, Guanghong Wei

Unraveling the Allosteric Mechanism of Four Cancer-related Mutations in the Disruption of p53-DNA Interaction

In The Journal of Physical Chemistry B, 2021.

doi:10.1021/acs.jpcb.1c05638

Priyadarshi Chakraborty, Hadas Oved, Darya Bychenko, Yifei Yao, Yiming Tang, Shai Zilberzwige‐Tal, Guanghong Wei, Tal Dvir, Ehud Gazit

Nanoengineered Peptide‐Based Antimicrobial Conductive Supramolecular Biomaterial for Cardiac Tissue Engineering

In Advanced Materials, 2021.

doi:10.1002/adma.202008715

Santu Bera, Xuewei Dong, Bankala Krishnarjuna, Shannon A. Raab, David A. Hales, Wei Ji, Yiming Tang, Linda J.W. Shimon, Ayyalusamy Ramamoorthy, David E. Clemmer, Guanghong Wei, Ehud Gazit

Solid-state packing dictates the unexpected solubility of aromatic peptides

In Cell Reports Physical Science, 2021.

doi:10.1016/j.xcrp.2021.100391

Xuewei Dong, Santu Bera, Qin Qiao, Yiming Tang, Zenghui Lao, Yin Luo, Ehud Gazit, Guanghong Wei

Liquid–Liquid Phase Separation of Tau Protein Is Encoded at the Monomeric Level

In The Journal of Physical Chemistry Letters, 2021.

doi:10.1021/acs.jpclett.1c00208

Xuewei Dong, Yiming Tang, Chendi Zhan, Guanghong Wei

Green tea extract EGCG plays a dual role in Aβ42 protofibril disruption and membrane protection: A molecular dynamic study

In Chemistry and Physics of Lipids, 2021.

doi:10.1016/j.chemphyslip.2020.105024

Chendi Zhan, Zenghui Lao, Yiming Tang, Qin Qiao, Guanghong Wei

Natural stereoisomeric flavonoids exhibit different disruptive effects and the mechanism of action on Aβ 42 protofibril

In Chemical Communications, 2021.

doi:10.1039/d1cc00404b

2020

Yifei Yao, Yiming Tang, Guanghong Wei

Epigallocatechin Gallate Destabilizes α-Synuclein Fibril by Disrupting the E46–K80 Salt-Bridge and Inter-protofibril Interface

In ACS Chemical Neuroscience, 2020.

doi:10.1021/acschemneuro.0c00598

Priyadarshi Chakraborty, Yiming Tang, Tom Guterman, Zohar A. Arnon, Yifei Yao, Guanghong Wei, Ehud Gazit

Co‐Assembly between Fmoc Diphenylalanine and Diphenylalanine within a 3D Fibrous Viscous Network Confers Atypical Curvature and Branching

In Angewandte Chemie International Edition, 2020.

doi:10.1002/anie.202009488

Yiming Tang, Yifei Yao, Guanghong Wei

Structural and dynamical mechanisms of a naturally occurring variant of the human prion protein in preventing prion conversion

In Chinese Physics B, 2020.

doi:10.1088/1674-1056/aba9ba

Kai Tao, Yiming Tang, Sigal Rencus‐Lazar, Yifei Yao, Bin Xue, Sharon Gilead, Guanghong Wei, Ehud Gazit

Bioinspired Supramolecular Packing Enables High Thermo‐Sustainability

In Angewandte Chemie International Edition, 2020.

doi:10.1002/anie.202008702

Chendi Zhan, Yujie Chen, Yiming Tang, Guanghong Wei

Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ42 Protofibril

In ACS Chemical Neuroscience, 2020.

doi:10.1021/acschemneuro.0c00277

Cuiqin Bai, Zenghui Lao, Yujie Chen, Yiming Tang, Guanghong Wei

Pristine and Hydroxylated Fullerenes Prevent the Aggregation of Human Islet Amyloid Polypeptide and Display Different Inhibitory Mechanisms

In Frontiers in Chemistry, 2020.

doi:10.3389/fchem.2020.00051

Priyadarshi Chakraborty, Yiming Tang, Tomoya Yamamoto, Yifei Yao, Tom Guterman, Shai Zilberzwige‐Tal, Nofar Adadi, Wei Ji, Tal Dvir, Ayyalusamy Ramamoorthy, Guanghong Wei, Ehud Gazit

Unusual Two‐Step Assembly of a Minimalistic Dipeptide‐Based Functional Hypergelator

In Advanced Materials, 2020.

doi:10.1002/adma.201906043

Yiming Tang, Yifei Yao, Guanghong Wei

Expanding the structural diversity of peptide assemblies by coassembling dipeptides with diphenylalanine

In Nanoscale, 2020.

doi:10.1039/c9nr09317f

Le Li, Xuhua Li, Yiming Tang, Zenghui Lao, Jiangtao Lei, Guanghong Wei

Common cancer mutations R175H and R273H drive the p53 DNA-binding domain towards aggregation-prone conformations

In Physical Chemistry Chemical Physics, 2020.

doi:10.1039/c9cp06671c

Yu Zou, Zhenyu Qian, Yehong Gong, Yiming Tang, Guanghong Wei, Qingwen Zhang

Critical nucleus of Greek-key-like core of α-synuclein protofibril and its disruption by dopamine and norepinephrine

In Physical Chemistry Chemical Physics, 2020.

doi:10.1039/c9cp04610k

2019

Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J. W. Shimon, Michael R. Sawaya, Sofiya Kolusheva, David S. Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei, Ehud Gazit

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

In Nature Communications, 2019.

doi:10.1038/s41467-019-13250-x

Hongqing Wang, Qian Xu, Zhihua Liu, Yiming Tang, Guanghong Wei, Y. Ron Shen, Wei-Tao Liu

Gate-Controlled Sum-Frequency Vibrational Spectroscopy for Probing Charged Oxide/Water Interfaces

In The Journal of Physical Chemistry Letters, 2019.

doi:10.1021/acs.jpclett.9b01908

Zenghui Lao, Yujie Chen, Yiming Tang, Guanghong Wei

Molecular Dynamics Simulations Reveal the Inhibitory Mechanism of Dopamine against Human Islet Amyloid Polypeptide (hIAPP) Aggregation and Its Destabilization Effect on hIAPP Protofibrils

In ACS Chemical Neuroscience, 2019.

doi:10.1021/acschemneuro.9b00393

Vasantha Basavalingappa, Tom Guterman, Yiming Tang, Sivan Nir, Jiangtao Lei, Priyadarshi Chakraborty, Lee Schnaider, Meital Reches, Guanghong Wei, Ehud Gazit